Plant-derived EpCAM antigen induces protective anti-cancer response
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چکیده
منابع مشابه
A plant-derived human monoclonal antibody induces an anti-carbohydrate immune response in rabbits.
A common argument against using plants as a production system for therapeutic proteins is their inability to perform authentic N-glycosylation. A major concern is the presence of beta 1,2-xylose and core alpha 1,3-fucose residues on complex N-glycans as these nonmammalian N-glycan residues may provoke unwanted side effects in humans. In this study we have investigated the potential antigenicity...
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Article Type: Review There are many difficulties and deficiencies in chemotherapeutic drugs especially drug resistances that appear in cancer chemotherapy. In spite of the fact that chemotherapeutic drugs are very effective, severe side effects limit the use of these drugs. People have to pay more attention to natural sources of cancer drugs to increase the anti-cancer agents present in the dru...
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Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone. We intend to summarize their anti-cancer effects and investigate the mechan...
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The currently available human vaccine for anthrax, derived from the culture supernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and edema factors, which may contribute to adverse side effects associated with this vaccine. Therefore, an effective expression system that can provide a clean, safe, and efficacious vaccine is required. In an effort to pro...
متن کاملHuman anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed
BACKGROUND: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors. The anti-anthrax toxin human monoclonal antibodies were evaluated for neutralization of anthrax lethal toxin in vivo in the Fisher 344 rat bolus toxin challenge model. METHODS: Human peripheral blood lymphocytes fr...
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ژورنال
عنوان ژورنال: Cancer Immunology, Immunotherapy
سال: 2007
ISSN: 0340-7004,1432-0851
DOI: 10.1007/s00262-007-0366-4